Painless, progressive weakness – Could this be motor neurone disease? Motor neurone disease (MND), a progressive and ultimately fatal neurodegenerative disease, is often difficult to clinically diagnose. There is no single investigation specific to MND and no sensitive disease-specific biomarker. Diagnosis is based on symptoms, clinical findings and the results of electrodiagnostic, neuroimaging and laboratory studies. Rapid and accurate diagnosis is crucial to ensuring the needs of people living with MND are met from the earliest possible stage. ...