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Australian Family Physician
Australian Family Physician

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Volume 39, Issue 9, September 2010

Oral hypoglycaemics A review of the evidence

Stephen M Twigg Patrick J Phillips
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Background
The range of oral hypoglycaemic agents (OHAs) has increased from one insulin sensitiser (metformin) and one class of insulin secretagogues (sulphonylureas) with the addition of further class of insulin secretagogues (glitinides), a further class of insulin sensitisers (glitazones) and two new classes: an alpha glycosidase inhibitor and glucagon-like peptide agents. Recent data has influenced the recommended sequence and usage of OHAs and glycaemic targets.
Objective
This article reviews the recent evidence in type 2 diabetes about the pros and cons of oral hypoglycaemic agents and the benefits and costs of intensive glycaemic control. It suggests a stepwise approach to glycaemic control with OHAs according to the evidence base currently available.

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Printed from Australian Family Physician - https://www.racgp.org.au/afp/2010/september/oral-hypoglycaemics-a-review-of-the-evidence
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