Australian Family Physician
Australian Family Physician


Volume 39, Issue 7, July 2010

Warfarin Indications, risks and drug interactions

Rami Tadros Sepehr Shakib
Download article
Cite this article    BIBTEX    REFER    RIS

Warfarin is a commonly used medication for the prevention and treatment of venous thromboembolism. It can be challenging for both the patient and the prescriber to manage at times.
To describe the mechanism of action of warfarin, and to discuss the indications for warfarinisation, the risks associated with warfarin use, and some of its drug interactions.
The common indications for warfarinisation are atrial fibrillation, venous thromboembolism and prosthetic heart valves. Contraindications include absolute and relative contraindications, and an individualised risk-benefit analyses is required for each patient. There are many interactions with warfarin, including pharmacokinetic and pharmacodynamic. Pharmacokinetic interactions can be monitored by using International Normalised Ratio levels. Pharmacodynamic interactions require knowledge by the prescriber to predict any interactions with warfarin, and International Normalised Ratio monitoring assists.

Download the PDF for the full article.

Download article PDF


Australian Family Physician RACGP

Printed from Australian Family Physician - https://www.racgp.org.au/afp/2010/july/warfarin-indications-risks-and-drug-interactions
© The Australian College of General Practitioners www.racgp.org.au