The incidence of melanoma continues to rise in Australia.
General practitioners treat the majority of skin cancers affecting
Australians. In the past decade, there has been improved uptake
of dermoscopy by GPs who realise its value in the assessment of
pigmented and nonpigmented lesions.
This article outlines those variants or presentations of melanoma
that create diagnostic difficulty for all clinicians. Practice tips
regarding clinical features or useful dermoscopic clues are
A clinical overview of lentigo maligna, acral lentiginous and
subungual melanoma, nodular melanoma, desmoplastic
melanoma, verrucous melanoma and hypomelanotic melanoma
is presented. Dermoscopy has become a vital diagnostic
aid in the assessment of all skin lesions. Its value in the
diagnosis of melanoma is highlighted where relevant. Expert
dermatopathology assessment is equally as crucial in reaching a
correct diagnosis, especially for some of these atypical variants.
Given that the prognosis associated with cutaneous malignant melanoma is closely associated with tumour thickness, it is imperative that melanomas are diagnosed at the earliest stage possible. When melanoma is suspected, early excisional biopsy or urgent referral is the most critical management step. Readers are urged to familiarise themselves with the current national recommendations regarding biopsy techniques, appropriate excision margins, relevant investigations and appropriate follow up, which are outlined in the recently revised Australian Cancer Network Melanoma clinical practice guidelines.1
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