B. Ceramide based cream as required (Score: 1)
C. Cognitive behavioural therapy (Score: 1)
F. Fluoxetine 20 mg daily (Score: 1)
H. Mometasone furoate 0.1% ointment topically once daily until skin is clear (Score: 1)
This is a four answer multiple selection question with pharmacological and non-pharmacological management options. This question presents a woman with a provisional diagnosis of obsessive-compulsive disorder, with compulsive hand washing resulting in hand dermatitis. Management options address both aspects of the diagnosis and include pharmacological and non-pharmacological options.
First line treatment of obsessive-compulsive disorder includes cognitive behavioural therapy and exposure and response prevention, and selective serotonin reuptake inhibitors. Treatment of her hand washing dermatitis includes use of emollients and short courses of topical corticosteroids. Ceramide-based emollients are likely to be more effective than sorbolene cream given the provided history. Molly has already tried hydrocortisone acetate 0.5% topically, so a more potent topical corticosteroid is indicated. Oral corticosteroids may be needed in severe cases however in the given scenario it is reasonable to trial a more potent topical corticosteroid first.
There are no strong features of depression or neuropathic pain, and Molly has not described difficulty sleeping, therefore agomelatine, pregabalin, promethazine and suvorexant are not indicated. Diazepam is not recommended first-line in obsessive compulsive disorder. Eye movement desensitisation and reprocessing therapy is used in post-traumatic stress disorder, which is a less likely diagnosis given the key features. Single session psychological debriefing is not appropriate in this case.
Imiquimod cream is used in treatment of warts and solar keratoses. Mupirocin is used in bacterial skin infections. Terbinafine is used in fungal skin infections.