The standard dose of Paxlovid is 300 mg of nirmatrelvir (two 150 mg tablets) together with 100 mg of ritonavir (one tablet). All tablets must be taken together, with or without food. The tablets should be swallowed whole and not chewed, broken or crushed.
The tablets are dispensed in pre-dosed blistered cards.
Paxlovid is taken every 12 hours for five days. If patients miss a dose, they should not take a double dose to make up for the missed dose and should take their next dose as scheduled. Patients should not stop taking Paxlovid or change their dosage without speaking to their GP or physician.
Dosage adjustment for patients with renal impairment
Patients with moderate renal impairment (eGFR ≥30 to <60 mL/min) can be prescribed a lower dose of 150 mg nirmatrelvir (one tablet) with one 100 mg tablet of ritonavir. Paxlovid is contraindicated in patients with severe renal impairment (eGFR <30 mL/min). Refer to the product information for further details on dose adjustment.
Patients receiving an adjusted dose must be made aware that as the tablets are dispensed in pre-dosed blistered cards, only one tablet of nirmatrelvir with the tablet of ritonavir should be taken every 12 hours.