Recommendation
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Grade
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References
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Recommended as of: |
Calculate cardiovascular disease (CVD) risk level using the Australian absolute cardiovascular disease risk calculator (Aus CVD Risk Calculator)*.
Age ranges for assessing CVD risk in people without known CVD are as follows:
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All people aged 45–79 years
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People with diabetes aged 35–79 years
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Aboriginal and Torres Strait Islander people aged 30–79 years. Assess individual CVD risk factors in Aboriginal and Torres Strait Islander people aged 18–29 years**
*The updated Aus CVD Risk Calculator can be accessed here. When using the calculator within electronic medical records, verify the version to ensure it is not outdated.
**Refer to the National Aboriginal Community Controlled Health Organisation (NACCHO)–Royal Australian College of General Practitioners (RACGP) National guide to preventive healthcare for Aboriginal and Torres Strait Islander people.
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Conditional
Conditional
Consensus
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1
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14/11/2024
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For Aboriginal and Torres Strait Islander people, consider reclassifying estimated CVD risk to a higher risk category after assessing the person’s clinical, psychological and socioeconomic circumstances, and community CVD prevalence.*
Refer to the NACCHO-RACGP National guide to preventive healthcare for Aboriginal and Torres Strait Islander people.
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Conditional, moderate
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1
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14/11/2024
|
In people whose estimated CVD risk is close to the threshold for a higher risk category, consider reclassifying estimated CVD risk to a higher risk category for the following groups:
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people of South Asian ethnicity (Indian, Pakistani, Bangladeshi, Sri Lankan, Nepali, Bhutanese, or Maldivian ethnicities)
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Conditional, moderate
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1
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14/11/2024
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People with pre-existing CVD are at high risk of another CVD event.
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Consensus
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2
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14/11/2024
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Managing CVD risk
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For people at high risk of CVD* (estimated 5-year risk ≥10% determined using the Australian cardiovascular disease risk calculator), prescribe lipid-modifying medicines to reduce CVD risk, unless contraindicated or clinically inappropriate. Explain the potential benefits and harms of treatment to the person and encourage shared decision-making. Encourage, support and advise a healthy lifestyle.
* For people at intermediate or low risk of CVD, refer to the Australian guideline for assessing and managing CVD risk.
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Strong
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1
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14/11/2024
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For people at high risk of CVD* (estimated 5-year risk ≥10% determined using the Australian CVD risk calculator), prescribe blood pressure-lowering medicines to reduce CVD risk, unless contraindicated or clinically inappropriate. Explain the potential benefits and harms of treatment to the person and encourage shared decision-making. Encourage, support and advise a healthy lifestyle.
* For people at intermediate or low risk of CVD, refer to the Australian guideline for assessing and managing CVD risk.
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Strong
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1
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14/11/2024
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We recommend the addition of an sodium–glucose cotransporter 2 inhibitor (SGLT2i) to other glucose-lowering medication(s) in adults with type 2 diabetes who also have CVD, multiple cardiovascular risk factors* and/or kidney disease.
*We define multiple cardiovascular risk factors as men 55 years of age or older or women 60 years of age or older with type 2 diabetes who have one or more additional traditional risk factors, including hypertension, dyslipidaemia or smoking.
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Strong
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3
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14/11/2024
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We recommend the addition of a glucagon-like peptide-1 receptor agonist (GLP-1RA) to other glucose-lowering medication(s) in adults with type 2 diabetes who have CVD, multiple cardiovascular risk factors* and/or kidney disease, and are unable to be prescribed an SGLT2i due to either intolerance or contraindication.
*We define multiple cardiovascular risk factors as men 55 years of age or older or women 60 years of age or older with type 2 diabetes who have one or more additional traditional risk factors, including hypertension, dyslipidaemia or smoking.
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Strong
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3
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14/11/2024
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Antihypertensive medication
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Antihypertensive therapy is strongly recommended in patients with diabetes and systolic blood pressure ≥140 mmHg.
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Strong; Level I evidence
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4
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14/11/2024
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For people with diabetes and hypertension, blood pressure targets should be individualised through a shared decision-making process that addresses cardiovascular risk, potential adverse effects of antihypertensive medications and individual preferences
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B
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5
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14/11/2024
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In patients with diabetes and hypertension, any of the first-line* antihypertensive drugs that effectively lower blood pressure are recommended.
*Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker (ARB) agents.5
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Strong; Level I evidence
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4
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14/11/2024
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In patients with diabetes and hypertension, chronic kidney disease or comorbidities of heart disease, a blood pressure target of <140/90 mmHg is recommended.
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Strong; Level I evidence
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4
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14/11/2024
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For individuals with hypertension and a history of transient ischemic attack (TIA) or stroke, a blood pressure target of <140/90 mmHg is recommended.
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Strong; Level I evidence
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4
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14/11/2024
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Lipid-lowering medications
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All adults with type 2 diabetes and known prior CVD (except haemorrhagic stroke) should receive the maximum tolerated dose of a statin, irrespective of their lipid levels.
Note: The maximum tolerated dose should not exceed the maximum available dose (eg 80 mg atorvastatin, 40 mg rosuvastatin).
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A
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2
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14/11/2024
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In people with type 2 diabetes and known prior CVD, fibrates should be commenced in addition to a statin or on their own (for those intolerant to statin) when fasting triglycerides are greater than or equal to 2.3 mmol/L, or high-density lipoprotein (HDL) cholesterol is low†.
Note: When used in combination with statins, fenofibrate presents a lower risk of adverse events than other fibrates combined with statins.
†HDL <1.0 mmol/L (based on the cut-offs reported in the ACCORD and FIELD studies).
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B
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2
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14/11/2024
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In individuals with atherosclerotic CVD (ASCVD) or other cardiovascular risk factors on a statin with controlled low-density lipoprotein (LDL) cholesterol but elevated triglycerides (135–499 mg/dL [1.5–5.6 mmol/L]), the addition of icosapent ethyl can be considered to reduce cardiovascular risk.
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A
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5
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14/11/2024
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For people with diabetes and ASCVD, treatment with high-intensity statin therapy is recommended to target an LDL cholesterol reduction of ≥50% from baseline and an LDL cholesterol goal of <55 mg/dL (<1.4 mmol/L). Addition of ezetimibe or a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor/PCSK9 targeted therapies with proven benefit in this population is recommended if this goal is not achieved on maximum tolerated statin therapy.
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B
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5
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14/11/2024
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Antithrombotic medication
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All adults with type 2 diabetes and known prior CVD should receive long-term antiplatelet therapy unless there is a clear contraindication.
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A
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2
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14/11/2024
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Use aspirin therapy (75–162 mg/day) as a secondary prevention strategy in those with diabetes and a history of ASCVD*.
*Based on a clinical history of atherosclerotic disease not imaging retinopathy risk reduction.
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A
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5
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14/11/2024
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For individuals with ASCVD and documented aspirin allergy, clopidogrel (75 mg/day) should be used*.
*Based on a clinical history of atherosclerotic disease not imaging retinopathy risk reduction.
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B |
5 |
14/11/2024
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