People with diabetes should be seen several weeks before surgery for assessment of glycaemic management and anaesthetic suitability, including their cardiovascular disease risks, and any treatment modifications instituted and stabilised from the time of referral before proceeding to surgery.
Attaining glycaemic goals (ie a glycated haemoglobin [HbA1c] approaching 7% [53 mmol/mol]) in the preoperative period has been shown to result in fewer complications and shorter hospital stays after surgery.22 A patient with an HbA1c ≥9% (75 mmol/mol) may need to have their surgery delayed until glycaemic management is optimised.22
Preoperative care is the same for minor and major surgery. For prolonged procedures, blood glucose levels should be monitored intra- and postoperatively for several days.
Insulin may be required postoperatively for some people with type 2 diabetes.
Further information can be found in the Australian Diabetes Society’s Peri-operative diabetes management guidelines22 and the Australian Diabetes Society alert regarding DKA with SGLT2i use in people with diabetes.5
Rural GPs who perform operations and GPs who administer anaesthetics should refer to the Peri-operative diabetes management guidelines22 to guide the advice they give to people in their care.
In practice
Ceasing medication before surgery
Appropriate written instructions should be given to people beforehand.
People who are prescribed oral glucose-lowering medications except SGLT2i, and people on injectable GLP-1RAs:
- can continue their diabetes medications on the day prior to surgery (be aware that gastric emptying is affected by GLP-1RAs and this may affect anaesthetic risks; also note that ceasing weekly dosed agents may not alter these risks due to their long drug half-lives, so notify anaesthetic teams preoperatively if they apply to any clinical case)
- should omit their oral glucose-lowering medications on the morning of surgery, regardless of whether they are on the morning or afternoon list.
SGLT2i should be reviewed prior to surgery and procedures that require one or more days in hospital and/or require bowel preparation, including endoscopy/colonoscopy (two days prior to and the day of the procedure), to prevent DKA in the perioperative period.5 Other glucose-lowering medications may need to be increased in this period.5
Specifically, with SGLT2i use, the Australian Diabetes Society has guidelines for temporary cessation prior to procedures (noting that other glucose-lowering medications may need adjustment to variable glucose levels) as follows:5
- For surgery and procedures requiring one or more days in hospital, omit SGLT2i for at least three days (ie two days before the procedure and on the day of procedure). This may require increasing other glucose-lowering drugs during that time. If the SGLT2i is part of a fixed dose combination, this will lead to withdrawal of two glucose-lowering drugs unless the second drug is prescribed separately.
- For surgery and procedures including colonoscopy requiring bowel preparation with carbohydrate restriction commencing on the day prior to the procedure, omit SGLT2i for at least three days (i.e. two days before and on the day of the procedure).
- For day-stay procedures (including gastroscopy) that do not require bowel preparation, SGLT2i can be stopped just for the day of the procedure. However, fasting before and after the procedure should be minimised.
Insulin and surgery
Insulin requires individualised advice as follows, and is usually not completely omitted (never withhold basal insulin):
- long-acting (basal) insulin – continue as usual (including morning doses)
- rapid/short-acting (prandial) insulin – omit rapid/short-acting insulin if not eating; depending on timing of procedure:
- morning procedure: withhold rapid/short-acting insulin (and all oral glucose-lowering medication)
- afternoon procedure: take half the normal morning rapid/short-acting dose in the morning before a light breakfast
- premixed insulin – take one-third to half the usual morning dose on the day of the procedure.
People taking intermediate-acting (basal) insulin who are booked for afternoon procedures or are on prolonged fasting may need a reduced dose. Seek specialist endocrinology and anaesthetic advice before planned procedures.
People on a multiple daily insulin regimen might require perioperative glucose infusion and associated close blood glucose monitoring. Many hospitals have a protocol or working plan that should be followed for the individual in that service.
Insulin may be recommenced with oral intake, with appropriate SMBG to guide dose adjustments.
Recommencing oral medication
People on oral glucose-lowering medication, with the exception of SGLT2i, can generally recommence medications when they are able to eat meals. Specific advice is available in Australian Diabetes Society’s Peri-operative diabetes management guidelines.22
SGLT2i should only be recommenced postoperatively when the person is eating and drinking normally or close to discharge from hospital. People who have had day surgery should only recommence SGLT2i once they are on full oral intake. It may be prudent to delay recommencement for another 24 hours; however, this must be balanced against the risk of hyperglycaemia.5
Metformin can generally be recommenced 24 hours after major surgery, provided there has been no deterioration in serum creatinine.22 For people using metformin and SGLT2i pre- and postoperatively, the maintenance of hydration and carbohydrate intake is important.
People undergoing colonoscopy
For colonoscopy preparation, Colonlytely or Glycoprep (rather than Fleet or Phosphoprep) should be used in people with renal impairment, who may become severely hyperphosphataemic with phosphate preparations.23
The dietary modifications that are advised for colonoscopy preparation might alter glucose management and hypoglycaemic risks; instruction on appropriate SMBG testing may be required. It is also essential to avoid excessive carbohydrate restriction during the bowel preparation period if the person has been using SGLT2i.
On preparation days and the day of the procedure, commence SMBG and withhold all oral medications. Note that SGLT2i should be ceased three days before colonoscopy and only recommenced when the person is eating and drinking normally.5
Basal and/or rapid-acting insulin should be managed as above.
Premixed insulin should be managed as follows:
- on the day of bowel preparation, reduce premixed dose by half for all doses
- on the day of the procedure, arrange a morning procedure and use half the usual dose and glucose infusion.