|
Type
|
Brand name
|
Manufacturer
|
Nature
|
|
Mealtime or prandial insulins
|
|
Ultra rapid-acting (onset in 5–10 minutes, peak at 30 minutes, duration for 3.5–4 hours)
|
|
Faster insulin aspart
|
FiAsp
|
Novo Nordisk
|
Analogue
|
|
Rapid-acting (onset in 15–20 minutes, peak at 1 hour, duration for 3.5–4.5 hours)
|
|
U200 Insulin lispro
|
Humalog
|
Lilly
|
Analogue
|
|
Insulin aspart
|
NovoRapid
|
Novo Nordisk
|
Analogue
|
|
Insulin glulisine
|
Apidra
|
Sanofi
|
Analogue
|
|
Short-acting (onset in ~1 hour, peak at 2–5 hours, duration for 6–8 hours)
|
|
Neutral
|
Actrapid
|
Novo Nordisk
|
Human
|
|
|
Humulin R
|
Lilly
|
Human
|
|
Basal insulins
|
|
Intermediate-acting
|
|
Isophane
|
Humulin NPH
|
Lilly
|
Human
|
|
|
Protaphane
|
Novo Nordisk
|
Human
|
|
Insulin detemir
Onset in 3–4 hours, peak at 3–8 hours, duration for 20–24 hours
|
Levemir
|
Novo Nordisk
|
Analogue
|
|
Insulin glargine (U100)
Onset in 1–2 hours, flat, duration for 18–24 hours
|
Optisulin
|
Sanofi
|
Analogue
|
|
|
Semglee
|
Alphapharm
|
Analogue
|
|
Insulin glargine (U300)
Onset in 1–2 hours, flat, duration for 24–36 hours
|
Toujeo
|
Sanofi
|
Analogue
|
|
Premixed insulins
|
|
Lispro 25%/lispro protamine 75%
Onset in 15–20 minutes, peak at 1 hour, duration for 14–24 hours
|
Humalog Mix 25
|
Lilly
|
Analogue
|
|
Lispro 50%/lispro protamine 50%
Onset in 15–20 minutes, peak at 1 hour, duration for 14–24 hours
|
Humalog Mix 50
|
Lilly
|
Analogue
|
|
Insulin aspart 30%/insulin aspart protamine 70%
Onset in 15–20 minutes, peak at 1 hour, duration for 14–24 hours
|
NovoMix 30
|
Novo Nordisk
|
Analogue
|
|
Neutral 30%/isophane 70%
Onset in 1–2 hours, peak at 2–5 hours, duration for 12–18 hours
|
Humulin 30/70
|
Lilly
|
Human
|
|
|
Mixtard 30/70
|
Novo Nordisk
|
Human
|
|
Insulin co-formulation
|
|
Insulin degludec 70% and insulin aspart 30%
Onset in 5–20 minutes, peak at 1 hour, duration for 36–48 hours
|
Ryzodeg 70/30
|
Novo Nordisk
|
Analogue
|
Notes:
ltra-rapid acting insulin should be administered from up to 2 minutes before a meal, at the start of a meal, or up to 20 minutes after starting a meal.
Rapid-acting, pre-mixed and co-formulated insulin should be administered 15 minutes prior to a meal.
Short-acting insulin should be administered 20–30 minutes prior to a meal.
Intermediate- and long-acting basal insulins can be given regardless of a meal. |