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2022 RACGP curriculum and syllabus
for Australian general practice
The Abuse and violence: working with our patients in general practice provides the best-available current evidence for GPs
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Coronavirus (COVID-19) resources for general practitioners
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Genomics in general practice
Disease specific topics
Types 1 and 2 diabetes are multifactorial.
Polygenic risk scores for type 1 and type 2 diabetes exist but their clinical utility remains uncertain.
MODY typically presents in the second to fourth decade of life, and does not fit the typical clinical picture of either types 1 or 2 diabetes. Presentation is often subacute or incidental. Many are misdiagnosed as types 1 or 2 diabetes.
MODY is the only type of diabetes caused by a single gene mutation. Mutations in 13 genes are known to cause MODY. The most prevalent mutations are in the HNF1A, GCK and HNF4A genes. GCK-MODY constitutes 10–60% of all MODY cases.
Testing for MODY should be considered in individuals with early onset diabetes with atypical features (ie not clearly type 1 or type 2):
If MODY is suspected, assess risk using the calculator available at the UK site.
Individuals with suspected MODY should be referred to an endocrinologist for assessment and consideration of genetic testing.
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