Background
Type 2 diabetes is a condition where the body cannot produce enough insulin and/or becomes resistant to the effects of insulin. This usually develops slowly over years, providing a substantial pre-diabetes window period of opportunity to offer preventive interventions. Screening for diabetes is safe, accurate and cost-effective, and detects a substantial proportion of people who may not otherwise have been identified and received early intervention.7 There is consistent evidence that appropriate management of diabetes can prevent or delay the progression of complications such as heart attacks, eye disease and kidney failure.8
There is a strong focus on the prevention of type 2 diabetes because healthy living interventions, such as healthy diet, physical activity and healthy weight, can potentially stop diabetes from occurring in the first place1,9 and potentially reverse it after it is diagnosed.10 However, there are many structural barriers to access to and affordability of healthy foods for many Aboriginal and Torres Strait Islander people, and colonisation has disrupted traditional diets and knowledge of food systems (refer to Chapter 2: Healthy living and health risks, Healthy living and health risks, Healthy eating).
The proportion of Aboriginal and Torres Strait Islander people living with type 2 diabetes is 8% overall, and 12% of those who live in remote areas. This is more than three-fold the rate of non-Indigenous Australians after adjustment for age.2 Type 2 diabetes becomes more common with increasing age: 35% of Aboriginal and Torres Strait Islander people aged over 55 years have the condition.2 The prevalence of tye 2 diabetes varies greatly between communities, affecting up to 40% of adults in some remote areas, and is increasing in adolescents.11 Type 2 diabetes is a direct or indirect cause for 20% of deaths of Aboriginal and Torres Strait Islander people.12
Obesity is a major cause of type 2 diabetes; Aboriginal and Torres Strait Islander adults who are obese are seve-fold more likely as those of healthy weight or underweight to have diabetes (17% versus 2.4%, respectively).12 Obesity is a very strong predictor of who may get type 2 diabetes in the future; a study of non-diabetic Aboriginal adults in Central Australia found that those who were overweight or obese were 3.3-fold more likely to develop diabetes than those who were not.7
Overweight and obesity is increasingly common in childhood and adolescence. In Aboriginal and Torres Strait Islander children aged 2–14 years, the proportion of children who were overweight or obese increased from 30% in 2012–13 to 37% in 2018–19.2
Obesity is not easy to reverse, but it gives health providers a substantial opportunity to encourage and help manage the prevention of type 2 diabetes. (Refer to Chapter 15: Overweight and obesity.)
Screening and diagnosis
T2D can be a condition with few or no symptoms, so is often not diagnosed unless health practitioners specifically look for it. The 2012–13 Australian Aboriginal and Torres Strait Islander Health Survey included blood samples for over 3300 participants and detected one newly diagnosed case for every six people with known diabetes.13
Screening for undetected diabetes is an efficient method of preventing complications from this disease because treatments can be started earlier.7
Type 2 diabetes be a condition with few or no symptoms, so is often not diagnosed unless health practitioners specifically look for it. The 2012–13 Australian Aboriginal and Torres Strait Islander Health Survey included blood samples for over 3300 participants and detected one newly diagnosed case for every six people with known diabetes.13
Screening for undetected diabetes is an efficient method of preventing complications from this disease because treatments can be started earlier.7
Screening for diabetes should be on an opportunistic basis and/or annually in the primary care setting; this is supported by stronger evidence than the use of mass screening programs.7 Aboriginal and Torres Strait Islander people should be screened for diabetes from age 18 years, rather than from 40 years as in the general Australian population.7 Children with additional risk factors should be screened from the onset of puberty (age >10 years). Children are considered to have additional risk factors if they are overweight or obese, have a family history of diabetes, have high lipids, are on psychotropic treatment or whose mothers had diabetes during pregnancy.14 In addition, all women require screening during each pregnancy.15
Screening is via blood testing (fingerprick and/or laboratory testing; see below) and often done at the same time as other screening blood tests, such as cardiovascular risk assessment. In the general population, the AUSDRISK risk assessment tool is recommended as a screening tool in order to identify who needs further assessment, including blood testing; however, given the higher prevalence of type 2 diabetes in Aboriginal and Torres Strait Islander populations, blood testing rather than the AUSDRISK tool is recommended as the primary screening test.4
The three types of diagnostic tests for diabetes are blood glucose (random or fasting), HbA1c and an OGTT. If a person has a strongly positive blood glucose or HbA1c test result and has symptoms of diabetes, one test is enough. However, for everyone else, the diagnosis should be confirmed by retesting on a separate day to reduce error.4
Box 1 explains how to interpret the test results to diagnose diabetes.
Asymptomatic individuals with a single abnormal test should have the test repeated to confirm the diagnosis unless the result is unequivocally elevated.
Where a random plasma glucose level ≥5.6 mmol/L and <11.1 mmol/L is detected, fasting plasma glucose should be measured or an OGTT performed or HbA1c measured.
Results that are just below the threshold of diabetes can be called prediabetes; this includes IFG (which can be diagnosed on a fasting sample) or IGT (which, technically, can only be defined by an OGTT; see Box 2). Prediabetes is not a disease and there is some controversy as to the benefits of diagnosing it7,9 because the main recommended interventions involve managing exercise, diet, weight/obesity, smoking and blood pressure rather than commencing diabetes medication, and this cardiovascular risk reduction should ideally be promoted regardless of a label of ‘prediabetes’.
Blood glucose
A fingerprick glucose measurement (a point-of-care test on capillary blood) is easy to do and enables further action on the same visit. However, it is less accurate than sending a venous blood sample to the laboratory.
A laboratory test after fasting overnight is the most reliable, and FBG ≥7.0 mmol/L is diagnostic of diabetes. However, if the person is unlikely to return for a fasting test, then a random (non-fasting) fingerprick test is a practical alternative. The downside is that any result between 5.5 and 11 mmol/L on a random test is considered ‘equivocal’ and will require clarification via further testing 7
HbA1c
HbA1c ≥6.5% (48 mmol/mol) is another method for diagnosing diabetes. This is most accurately measured in a laboratory on a venous sample but can also be done via fingerprick using a point-of-care analyser. Fasting is unnecessary.
Point-of-care HbA1c testing for screening is now rebated through the Medicare Benefit Schedule (MBS). There is an MBS item for all practices accredited against both the RACGP Standards for general practices and Standards for point-of-care testing.16–18 There is also an MBS item, at a higher rebate, for health services enrolled in the Quality Assurance for Aboriginal and Torres Strait Islander Medical Services (QAAMS) pathology program.19 In remote settings particularly, a practical and accurate method is to do a fingerprick HbA1c test and, if the result is equivocal (just above or just below 6.5%), to confirm this with a laboratory HbA1c test.
Using HbA1c as a screening tool is less reliable in those with iron deficiency, recent iron or blood transfusions, haemoglobin variants or alterations in red blood cell turnover (including pregnancy).20 A ‘borderline’ HbA1c result in the range 6.0–6.4% (42–46 mmol/mol) suggests someone at future high risk of developing diabetes.21
Oral glucose tolerance test
An OGTT involves a venous blood sample after overnight fasting, then another sample two hours after drinking 75-g glucose solution. Besides being the preferred screening test in pregnancy, its other main use is to clarify an ‘equivocal’ FBG result. An OGTT is less convenient than an HbA1c test, but it can help sort out the diagnosis where there is uncertainty.
Obesity should be screened for opportunistically. The three common ways to measure obesity are BMI, waist circumference and the waist-to-hip ratio. A study in a remote Northern Territory community showed that waist circumference is a more accurate predictor of mortality risk than BMI.22 (Refer to Chapter 15: Overweight and obesity.)
There is no role for routinely testing insulin levels to assess insulin resistance.4