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Oral analgesics

Pharmacological interventions

Oral analgesics


 

Intervention: Paracetamol – Knee and/or hip

Recommendation

We are unable to recommend either for or against the use of paracetamol for people with knee and/or hip osteoarthritis (OA). However, it might be reasonable to trial paracetamol for a short period and then discontinue use if it is not effective. Clinicians also need to monitor and capture adverse events that may be associated with its use.

Strength of recommendation

Conditional (neutral) recommendation

Quality of evidence

Very low

Intervention: Oral NSAIDs including cyclooxygenase-2 (COX-2) inhibitors – Knee and/or hip

Recommendation

It may be appropriate to offer oral NSAIDs for some people with knee and/or hip OA. 

It might be reasonable to trial oral NSAIDs at the lowest effective dose for a short period, then discontinue use if not effective. Clinicians also need to inform individuals about, monitor and capture adverse events, especially gastrointestinal, renal and cardiovascular, which may be associated with use of NSAIDs.

Strength of recommendation

Conditional for recommendation

Quality of evidence

Moderate

Intervention: Oral opioids – Knee and/or hip

Recommendation

We do not recommend offering oral opioids for people with knee and/or hip OA.

Strength of recommendation

Strong against recommendation

Quality of evidence

Low (knee)
Very low (hip)

Intervention: Transdermal opioids – Knee and/or hip

Recommendation

We do not recommend offering transdermal opioids for people with knee and/or hip OA.

Strength of recommendation

Strong against recommendation

Quality of evidence

Low

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