Background Proton pump inhibitors (PPIs) are one of the most popularly prescribed drugs in Australia for conditions such as gastro-oesophageal reflux disease, peptic ulcer disease and functional dyspepsia. Despite their good safety profile, PPIs have potential adverse effects, yet they are often overprescribed and without a clear indication.
Objective This article reviews the uncommon adverse effects of PPIs and provides recommendations for managing patients receiving this therapy.
Discussion Uncommon adverse effects include rebound acid hypersecretion syndrome, fragility fractures, interstitial nephritis, electrolyte derangements, pneumonia, enteric infection and vitamin B12 deficiency. General practitioners should be aware of these potential adverse effects and ensure that PPIs are used appropriately and where benefit clearly outweighs any harmful effects.
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